In the present work two simple, precise, rapid and accurate UV spectrophotometric methods has been developed for the estimation of warfarin sodium clathrate from tablet dosage form. First method A was area under curve method in which areain the range of 300.00 - 320.00 nm was selected for the analysis. Second method B was first order derivative spectrophotometric methodin which absorbanceat λmin = 282.6 nm, λmax = 328.8 nm and zero cross = 310.41 nm was measured. The standard and sample solutions of warfarin sodium clathrate were prepared in methanol. The accuracy and precision of the methods were determined and validated statically. Both the methods showed good recovery and reproducibility with % RSD less than 2. The methods were found to be rapid, specific, precise and accurate andhence can be employed for routine analysis of warfarin sodium clathrate in bulk and its pharmaceutical dosage form.
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